>

NurseAid

Helping women to fulfill the promise: Embrace the Change.

Modern women are information seekers. And when it comes to menopause, you know better than anyone – change is inevitable. Let’s admit it: even though you may not always recognize every perimenopause or menopause symptom, you can tell when your body is changing; and no doubt you are savvy enough to make the connection.

Trying to be one step ahead, you may turn to your mother, older sister or friend for advice on how to address your own needs. But menopause is as emotionally complicated as it’s physically diverse, and you may not always have the same symptoms. That’s when having an ally and expert such as Amberen NurseAid can be a relief on its own.

Amberen NurseAid is a team of licensed nurses who provide one-on-one personalized consultations on menopause, perimenopause and Amberen. This free service is available to any woman going through menopause transition.

Regardless of the way you choose to manage your menopause, with Amberen’s help or without, NurseAid is your ally and go-to-resource for information. We guide, support, connect and educate because it’s all about you.

Don’t hesitate to speak about your menopause needs with one of our nurses! Here is how:

By calling (800) 211-8021 Monday-Friday 9 a.m. – 7 p.m. EST.

Send us an email: wecare@lunadabiomed.com

Chat with us: Click Here

Schedule a consultation at your convenience (coming soon)

Please note NurseAid provides consultations only during business hours Monday-Friday 9 a.m. – 7 p.m. EST.

NurseAid agents do not provide medical advice and should never be used as a substitute or alternative to seeking professional medical advice and treatment.
>

FAQs

Amberen is your go-to resource for information when it comes to menopause and perimenopause. We believe that the more women know about menopause and its symptoms, the easier the transition becomes. Below is a series of questions most asked the Amberen NurseAid.

If you still can’t find an answer to your question(s), Amberen NurseAid’s team of licensed nurses are available to answer any specific concerns†† you may have via a phone call (800) 211-8021, online chat or email Monday-Friday 9 a.m. – 7 p.m. EST. We look forward to hearing from you!

>

Clinical Trials

In 1971, a team of researchers reversed menopause in aging rats by restoring their hypothalamic function using an early prototype of Amberen. Since then, Amberen’s formulation and its main ingredients have been researched and clinically tested by renowned scientists and doctors to test its efficacy in helping women manage symptoms related to climacteric syndrome, or as it is more commonly known, menopause.

The scientific foundation that supports Amberen’s effectiveness and safety is substantial and includes three randomized, double-blind, placebo-controlled clinical studies on menopausal and perimenopausal women and over 45 years of research on its ingredients.

Here is the list of human clinical trials, report summaries and publications.

2015-2016, The Peoples’ Friendship University of Russia. Title: “Clinical evaluation of effectiveness and safety of supplement Amberen as a treatment for the climacteric syndrome”.

Summary: a double-blind, comparative, randomized, placebo-controlled 12-week study for the treatment of the climacteric syndrome. This trial involved one hundred and twenty five (125) menopausal and perimenopausal women, between 42 and 60 years of age, with mild to moderate menopausal symptoms. Based on the results of the statistical and dynamic analysis, the following symptoms showed statistically significant (p < 0.05) improvements in Amberen patients: hot flashes, night sweats, difficulty sleeping, increased excitability, difficulty concentrating, feeling tired or lacking energy, mood swings, irritability, headaches, muscle and joint aches and lack of sexual interest, among others. During the course of the treatment and by the end of the study, the patients who took Amberen showed dynamically significant increase in the estradiol levels and decreases in the levels of FSH and LH, body mass, hip and waste circumferences. Clinical evaluation of Amberen, including primary indicators (improvements in vasomotor, endocrine, and neuropsychiatric functions), proved Amberen to be a safe, well-tolerated, and effective therapy for the climacteric syndrome.

2014-2015, I.M. Sechenov Moscow State Medical University, University Hospital #2, OBGYN Clinic. Title: “Clinical evaluation of effectiveness and safety of supplement Amberen as a treatment for climacteric syndrome”.

Summary: a double-blind, comparative, randomized, placebo-controlled 12-week study for the treatment of the climacteric syndrome. The clinical trial involved one hundred two (102) menopausal and perimenopausal women, ranging from 42 to 60 years of age, with mild to moderate menopausal symptoms. Based on the results of the statistical and dynamic analysis, the following symptoms showed statistically significant (p < 0.05) improvements in Amberen patients: hot flashes, night sweats, irritability, mood swings, sleeplessness, stress and anxiety, difficulty concentrating, headaches, muscle and joint aches, and lack of sexual interest, among others. Dynamic and statistically significant changes in levels of estradiol, FSH and LH, body mass, and hip and waist circumferences were also observed. Clinical evaluation of Amberen, including primary indicators (improvements in vasomotor, endocrine, and neuropsychiatric functions), proved Amberen to be a safe and effective therapy for the climacteric syndrome.

2001, Ulianovsk medical hospital #1, Russia

Title: “Evaluation of Enerlit (current: Amberen) as a treatment for climacteric syndrome “.

Summary: a double-blind, randomized, placebo-controlled 90-day human clinical study for the treatment of climateric syndrom on seventy (70) menopausal women. Based on the results, Amberen-based therapy lowered many characteristics of menopausal symptoms with statistical significance when compared with placebo group. Those symptoms include hot flashes, sleeplessness, headache, irritability, fatigue and muscle and joint aches. A clinically important alleviation of low libido, headaches and other symptoms was also observed. Additionally, blood tests revealed that Amberen was increasing the levels of estradiol in those Amberen-treated participants whose estradiol was lower than normal in pre-trial period. No adverse side effects of Amberen were registered. The results of this study have been published in three out of four peer-reviewed publications below.

Publications (2005 – up to date):

  • Efficiency of alternative therapy in perimenopausal and postmenopausal women.

    Kuznetsova I.V., Uspenskaya Yu.B., Borisova N.I., Zhukova E.V., Berdnikova N.G., Gusak Yu.K. Efficiency of alternative therapy in perimenopausal and postmenopausal women. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016; (5): (in Russian) http://dx.doi.org/10.18565/aig.2016.5

  • Succinate-Based Preparation Alleviates Manifestations of the Climacteric Syndrome in Women.

    Succinate-Based Preparation Alleviates Manifestations of the Climacteric Syndrome in Women. Bulletin of Experimental Biology and Medicine, Vol. 140, No. 3 (New York, 2005).

  • A Succinate-Based Composition ‘Rejuvenates’ Aging Mice and Alleviates Menopausal Symptoms in Women Without Sex Hormone Replacement Therapy

    A Succinate-Based Composition ‘Rejuvenates’ Aging Mice and Alleviates Menopausal Symptoms in Women Without Sex Hormone Replacement Therapy. Medline, Vol. 8, Art. 46, at pp. 497-517 (2007).

  • A Succinate-Based Composition Reverses Menopausal Symptoms Without Sex Hormone Replacement Therapy.

    A Succinate-Based Composition Reverses Menopausal Symptoms Without Sex Hormone Replacement Therapy. Advances in Gerontology, Vol. 21, No. 2, at pp. 298-305 (2008).

  • Maintenance of homeostasis in the aging hypothalamus: the central and peripheral roles of succinate.

    Chen TT, Maevsky EI and Uchitel ML. Maintenance of homeostasis in the aging hypothalamus: the central and peripheral roles of succinate. Front. in Endocrinol. (2015) 6:7 doi.org/10.3389/fendo.2015.00007

Complete list of publications that comprise the body of science substantiating Amberen’s mechanism of action can be found here. Please note that many of these articles are available only in Russian language.

 

>

The Amberen Difference

The experience of menopause is unique to every woman. For some, there are a diverse range of physical symptoms, for others, the effects are more emotional. How to manage your own symptoms is a deeply personal choice.

Regardless of what path you choose to manage the changes in your body, the most important thing to look for in a supplement is effectiveness, safety, and thorough clinical testing.

Amberen’s mechanism of action: There are treatments that may mask some symptoms individually, but Amberen is different. Amberen primarily targets the root cause of menopause – hormonal imbalance. Amberen’s formula naturally re-activates the production of hormones your body lacks as a result of maturing. Taking Amberen during a clinically recommended 90-days course helps your body transition back, over time, to its former state of hormonal balance.

Amberen is a non-hormonal, non-herbal, clinically tested supplement for menopause symptom relief with no registered side effects. Amberen makes a positive difference in many women’s lives based on personal stories they share with us.

Multi-symptom menopause management: Menopause has many physical and emotional symptoms that effect every woman differently. Amberen is a multi-symptom relief supplement that individually addresses the root cause of hot flashes, mood swings, sleeplessness, fatigue and other symptoms in a single formulation.
Proprietary ingredients: While most supplements contain generic or herbal ingredients, Amberen is a unique non-herbal, non-hormonal supplement with ingredients produced trough a U. S. patented manufacturing process. Read more about Amberen ingredients here.

No side effects: Amberen has no registered side effects. This is substantiated by three randomized double-blind placebo-controlled clinical studies and over 45 years of rigorous research.**

45-day MBG: You can try Amberen for 45 days and if you are not satisfied with the results, we will refund 100% of the purchase price including delivery fees. (Restrictions apply, see Terms & Conditions.)

45-day money back guarantees is limited to oner per household andapplies exclusively to orders placed on amberen.com or by calling Customer Care at (800) 222-3304. If purchased by a retailer, individual retailer return policy terms apply.

How Else Does Amberen Compare?

Amberen Differents

>

Ingredients

Amberen ingredients are clinically tested, effective, innovative and safe.

Unlike other over-the-counter supplements in menopause relief category that mostly contain herbs or soy, Amberen is a proprietary blend of naturally occurring key intermediate metabolites such as salts of dicarboxylic acids (succinates and fumarates, components of Krebs cycle found in all living organisms ), amino acids, minerals and vitamin E that are the result of 45 years of rigorous research and clinical testing published in peer-reviewed journals. Lunada Biomedical, the maker of Amberen, owns the U.S. patents for the manufacturing technology of main ingredients.

Amberen’s safety and efficacy is supported by randomized, double-blind, placebo-controlled, clinical trials on menopausal women and decades of research.*

The Amberen daily regimen (also called the Amberen serving) consists of two small, easy-to-swallow gelatin capsules, one orange and one white, which should be taken once a day after breakfast.

Amberen proprietary compound includes:
chart

Here is more detailed information on each active ingredient.

Ammonium Succinate’s properties are mainly distinguished by:

  • fast absorption: as naturally occurring molecules, succinates and their derivatives quickly and easily cross biological membranes.
  • energy production: many studies have shown that the human aging process contributes to the decline of mitochondrial energy metabolism and increased mitochondrial oxidative stress. Succinate molecules act as fuel for mitochondria and help stabilize their energy-production processes.
  • mitochondrial antioxidant: ammonium succinate acts as an antioxidant and blocks the activity of free radicals, thus preventing them from causing damage.
  • toxic by-products elimination: ammonium succinate slows down the elimination of toxic by-products.

Calcium disuccinate is the source of calcium, which is vital for bone-tissue formation, nerve-signal transmission, muscle contractions, and blood clotting. The calcium disuccinate molecule is a chelating agent and aids in the transporting of calcium before it‘s absorbed in the digestive system. Because succinates are naturally occurring molecules, they cross cell membranes very efficiently.

Magnesium disuccinate is the source of magnesium, which is required for the activity of hundreds of enzymes, muscle relaxation, bone and heart health, the conduction of nerve impulses, maintaining blood pressure, and protein production. Again, because succinates are naturally occurring molecules, they cross cell membranes very efficiently.

Zinc difumarate is the source of zinc. This mineral is found in active centers of over 300 enzymes and is required for their proper functions. Zinc plays a key role in the synthesis and secretion of many hormones (e.g., insulin), functions of the immune system, normal growth and development, carbohydrate metabolism, and DNA synthesis.

Glycine is an amino acid involved in the processes regulating brain-cell activity. In combination with magnesium, it makes brain mitochondria more resistant to low-oxygen conditions (hypoxia), which, in turn, results in the normalization of the psycho-emotional balance in the body.

Vitamin E in its form as tocopheryl acetate, is a fat-soluble, natural antioxidant that prevents lipid peroxidation of cell membranes. Cell organelles and, most importantly, the DNA contained in the nucleus relies on the membrane to protect them. Antioxidative properties of tocopheryl, supplemented by water-soluble succinate anions, promote the stabilization of the membrane structure, as well as general cell functions.

Monosodium L-glutamate is a salt of an amino acid that functions as a neurotransmitter and regulates the chemical reactions of transamination. Amberen contains a safe, small amount—40 mg per each serving. Monosodium L-glutamate has been shown to positively affect the performance of mitochondrial-benzodiazepine receptors in peripheral tissues and stabilize energy status. For more details on this ingredient, please visit the FDA website.

>

Taking Amberen

Every woman’s transition is as unique as she is — it can be as emotionally complicated as it is physically diverse. What’s more, you may not experience the same symptoms as your mother, sister, or friends. It’s important to be aware of how your own body is adjusting and make choices for yourself. Here is some information on how to take Amberen.

Directions: Amberen is a daily regimen. This means you should take two capsules – one white and one orange – daily after breakfast. Consider drinking caffeine-free liquids when taking Amberen.

Recommended intake: For best menopause symptom relief, take Amberen for at least 90 days. Consider making Amberen your daily regimen to help your body maintain hormonal balance during perimenopause and menopause transition.

What to expect: Every woman’s results vary when it comes to symptom relief. You may notice the improvement of your symptoms quickly, or over time. Several factors may play a role, such as general health, lifestyle habits or any existing health issues. Clinical studies on menopausal women with mild to moderate symptoms have shown that significant menopause symptom relief was observed after 90-days of continuous intake of Amberen.*

Even though most women should notice improvements within the first 30 days, based on clinical testing we recommend to continue taking Amberen for at least 90 days to experience efficient symptom relief.

If your progress is slower than expected, don’t get discouraged. Consult NurseAid to inquire about adjustments to your Amberen regimen.

Caution: Amberen is not intended for use by pregnant or nursing women. Do not take if you have severe hypertension. If you are taking prescription medication or have any medical condition consult your doctor before use. Discontinue use and consult your doctor if you have any adverse reaction.

Maintaining hormonal balance is essential for your health and well-being. Amberen is an innovative daily regimen that naturally restores your body’s hormone production and provides comfort for the physical and emotional effects of perimenopause and menopause.

>

How Amberen Works

Those hot flashes and mood swings may leave you feeling less than your usual self, but remember, menopause isn’t an illness. Rather, it’s a natural part of maturing, triggered by decline in estrogen and the resulting hormonal imbalance.

The fact is, menopause and hormones go hand in hand.

Estrogen is a powerful hormone that regulates not only the reproductive organs of a woman’s body, but also a broad array of brain regions. Our brain both controls estrogen release through the hypothalamus–pituitary–gonadal (HPG, the core of female hormonal system) axis and responds to it, which is why the entire body is affected through this process.

What is the hypothalamus? It’s the part of the brain that regulates hormonal balance in your body. When functioning properly, the hypothalamus senses the lack of hormones and instructs the ovaries and pituitary glands to increase hormone production to keep the body regulated.

During the natural maturing process the hypothalamus loses some of its ability to receive signals from the hormone producing organs. This causes fluctuation of hormone levels like estrogen which brings on perimenopause and then menopause. In addition, the decline of estrogen triggers a variety of uncomfortable effects – hot flashes and night sweats, irritability, fatigue, sleeplessness and mood swings.

Specifically, Amberen’s blend of amino acids and minerals rejuvenates the hypothalamus and naturally restores its communication with the hormone producing organs. As a result, the ovaries start to naturally produce estrogen again which leads to hormonal balance. Restoring the balance of estrogen levels helps diminish the frequency and severity of menopausal symptoms *. That’s exactly what Amberen does. Amberen works effectively and without any adverse side effects, which is a relief on its own.

Amberen helps provide multiple symptom relief for menopause. Two recent randomized, double-blind, placebo-controlled clinical studies on menopausal women with mild to moderate symptoms have shown that Amberen helps alleviate and manage many of the most common symptoms of menopause, such as hot flashes, night sweats, mood swings, low energy, sleeplessness, difficulty concentrating, irritability, menopausal headaches and stress, loss of sexual interest, and muscle and joint aches*.