What sets Amberen® apart from other products is its proprietary ingredients produced via the U.S.-patented production process.
Amberen’s formulation is supported by 40 years of research.
Currently, there is no equivalent product on the market that naturally restores hormonal balance, which is known to be the cause of perimenopausal and menopausal symptoms. There double-blind, placebo-controlled, clinical trials have confirmed Amberen’s safety and efficacy.
The Amberen daily regimen (or Amberen dosage) consists of two capsules, one orange and one white, which should be taken once a day after breakfast.
The capsules are small and easy to swallow because Amberen’s ingredients have high potency and bioavailability; thus, small amount are enough to achieve the results.
Amberen Proprietary Compound includes:
- Ammonium succinate
- Calcium disuccinate
- Magnesium disuccinate
- Zinc difumarate
- Tocopherol acetate
- Pharmaceutical grade of monosodium L-glutamate
The main ingredient in Amberen is ammonium succinate (white capsule). Succinates are naturally occurring metabolic intermediates found in all living organisms.
Ammonium succinate’s properties are distinguished by:
As naturally occurring molecules, succinates and their derivatives quickly and easily penetrate biological membranes. This way, they act as a fast delivery vehicle of the essential minerals and vitamins found in the orange Amberen capsule.
Rejuvenation of the hypothalamus
Ammonium succinate functions as a signaling molecule activating the hypothalamus, the part of the brain responsible for hormone production by other organs. As the female body ages, hypothalamic function declines. This causes disruptions in hormone production, which results in unpleasant symptoms associated with menopause. Ammonium succinate rejuvenates the hypothalamus and, in turn, naturally restores hormonal balance.
Our body needs energy to sustain life. More than 90% of the body’s energy is generated inside specialized cell structures called mitochondria. Many studies have shown that the human aging process contributes to the decline of mitochondrial energy metabolism and enhanced mitochondrial oxidative stress. Succinate molecules act as fuel for mitochondria and help stabilize their energy-production processes.
Stabilization of mitochondrial activity
Although ammonium succinate contributes to mitochondria stimulation under the condition of energy and oxygen deficiency, it has an opposite effect in the event of mitochondrial hyperactivity. For example, hot flashes—one of the most common menopausal symptoms—require a lot of energy for the mitochondria to produce, which may result in mitochondrial hyperactivity. Ammonium succinate helps balance energy production and stabilize mitochondrial activity.
Succinate and fumarate act as mitochondrial antioxidants. During normal energy-production processes that constantly occur in the mitochondria, free radicals are being formed. These are the chemicals that play an important role in many normal cellular processes. However, under certain conditions, such as stress and low oxygen, which are common during menopause, high amounts of free radicals may be produced. At high concentrations, free radicals can be hazardous to the body and damage all major components of the cells, including DNA, proteins, and cell membranes. Ammonium succinate acts as an antioxidant and blocks the activity of free radicals, thus preventing them from causing damage. As a result, it neutralizes free radicals and slows down their production while allowing the energy-production processes to proceed.
Toxic by-products elimination
Ammonium succinate eases the elimination of toxic by-products. This is achieved by lowering the electrical threshold that the molecules have to overcome in order to cross cellular membranes.
Calcium disuccinate is the source of calcium, which is vital for bone-tissue formation, nerve-signal transmission, muscle contractions, and blood clotting. The calcium disuccinate molecule is designed to be activated and easily absorbed in the digestive system. Because succinates are naturally occurring molecules, they cross cell membranes very efficiently. They deliver calcium inside the cells, where it can be quickly incorporated into a variety of metabolic reactions.
Magnesium disuccinate is the source of magnesium, which is required for the activity of hundreds of enzymes, muscle relaxation, bone and heart health, the conduction of nerve impulses, maintaining blood pressure, and protein production. Again, because succinates are naturally occurring molecules, they cross cell membranes very efficiently. They deliver magnesium inside the cells, where—like calcium—it can be quickly incorporated into a variety of metabolic reactions.
Zinc difumarate is the source of zinc. This mineral is found in active centers of over 300 enzymes and is required for their proper functions. Zinc plays a key role in the synthesis and secretion of many hormones (e.g., insulin), functions of the immune system, normal growth and development, carbohydrate metabolism, and DNA synthesis.
Glycine is an amino acid involved in the processes regulating brain-cell activity. In combination with magnesium, it makes brain mitochondria more resistant to low-oxygen conditions (hypoxia), which, in turn, results in the normalization of the psycho-emotional balance in the body.
Vitamin E, in its form as tocopherol acetate, is a fat-soluble, natural antioxidant that prevents lipid peroxidation of cell membranes. Cell organelles and, most importantly, the DNA contained in the nucleus rely on the membrane to protect them. Antioxidative properties of tocopherol, supplemented by water-soluble succinate anions, promote the stabilization of the membrane structure, as well as general cell functions.
Monosodium L-glutamate is a salt of an amino acid that functions as a neurotransmitter and regulates the chemical reactions of transamination. Amberen contains a safe, small amount—40 mg per each serving of pharmaceutical-grade bioactive monosodium L-glutamate, which is very different from the quality and quantity of MSG used in processed foods. Monosodium L-glutamate has been shown to positively affect the performance of mitochondrial-benzodiazepine receptors in peripheral tissues and stabilize energy status.
For a more detailed explanation, please visit the FDA website: