Amberen ingredients are clinically tested, effective, innovative and safe.

Unlike other over-the-counter supplements in menopause relief category that mostly contain herbs or soy, Amberen is a proprietary blend of naturally occurring key intermediate metabolites such as salts of dicarboxylic acids (succinates and fumarates, components of Krebs cycle found in all living organisms ), amino acids, minerals and vitamin E that are the result of 45 years of rigorous research and clinical testing published in peer-reviewed journals. Lunada Biomedical, the maker of Amberen, owns the U.S. patents for the manufacturing technology of main ingredients.

Amberen’s safety and efficacy is supported by randomized, double-blind, placebo-controlled, clinical trials on menopausal women and decades of research.*

The Amberen daily regimen (also called the Amberen serving) consists of two small, easy-to-swallow gelatin capsules, one orange and one white, which should be taken once a day after breakfast.

Amberen proprietary compound includes:

Here is more detailed information on each active ingredient.

Ammonium Succinate’s properties are mainly distinguished by:

  • fast absorption: as naturally occurring molecules, succinates and their derivatives quickly and easily cross biological membranes.
  • energy production: many studies have shown that the human aging process contributes to the decline of mitochondrial energy metabolism and increased mitochondrial oxidative stress. Succinate molecules act as fuel for mitochondria and help stabilize their energy-production processes.
  • mitochondrial antioxidant: ammonium succinate acts as an antioxidant and blocks the activity of free radicals, thus preventing them from causing damage.
  • toxic by-products elimination: ammonium succinate slows down the elimination of toxic by-products.

Calcium disuccinate is the source of calcium, which is vital for bone-tissue formation, nerve-signal transmission, muscle contractions, and blood clotting. The calcium disuccinate molecule is a chelating agent and aids in the transporting of calcium before it‘s absorbed in the digestive system. Because succinates are naturally occurring molecules, they cross cell membranes very efficiently.

Magnesium disuccinate is the source of magnesium, which is required for the activity of hundreds of enzymes, muscle relaxation, bone and heart health, the conduction of nerve impulses, maintaining blood pressure, and protein production. Again, because succinates are naturally occurring molecules, they cross cell membranes very efficiently.

Zinc difumarate is the source of zinc. This mineral is found in active centers of over 300 enzymes and is required for their proper functions. Zinc plays a key role in the synthesis and secretion of many hormones (e.g., insulin), functions of the immune system, normal growth and development, carbohydrate metabolism, and DNA synthesis.

Glycine is an amino acid involved in the processes regulating brain-cell activity. In combination with magnesium, it makes brain mitochondria more resistant to low-oxygen conditions (hypoxia), which, in turn, results in the normalization of the psycho-emotional balance in the body . A recently published study suggests that glycine treatment can effectively prevent elderly fibroblasts from expressing age-associated respiration defects. Nature. Scientific Reports 5, Article number: 10434 (2015)doi:10.1038/srep10434

Vitamin E in its form as tocopheryl acetate, is a fat-soluble, natural antioxidant that prevents lipid peroxidation of cell membranes. Cell organelles and, most importantly, the DNA contained in the nucleus relies on the membrane to protect them. Antioxidative properties of tocopheryl, supplemented by water-soluble succinate anions, promote the stabilization of the membrane structure, as well as general cell functions.

Monosodium L-glutamate is a salt of an amino acid that functions as a neurotransmitter and regulates the chemical reactions of transamination. Amberen contains a safe, small amount—40 mg per each serving of pharmaceutical-grade bioactive monosodium L-glutamate, which is very different from the quality and quantity of MSG used in processed foods. Monosodium L-glutamate has been shown to positively affect the performance of mitochondrial-benzodiazepine receptors in peripheral tissues and stabilize energy status. For more details on this ingredient, please visit the FDA website.