Scientific & Clinical Research

We at Amberen, pride ourselves in the 45 years of scientific research on our primary ingredients and passionately believe in helping all women going through menopause. The scientific foundation that supports Amberen’s effectiveness and safety is substantial, which includes multiple clinical studies on menopausal women.* Since 2007, it’s been our mission to make every woman’s transition as symptom-free as possible.

Expert Opinion

“Amberen is a safe non-hormonal option for my patients suffering from hot flashes, night sweats, mood swings and other menopausal symptoms.”

Prof. Lee Shulman
M.D., OB-GYN
Amberen’s Board of
Scientific Advisors

“Amberen is a safe non-hormonal option for my patients suffering from hot flashes, night sweats, mood swings and other menopausal symptoms.”

Prof. Lee Shulman
M.D., OB-GYN
Amberen’s Board of
Scientific Advisors

Clinically Shown Results

Clinically Shown Results

A published 12-week randomized, placebo-controlled, double-blind study on women, between 42-60 years of age with mild to moderate menopause symptoms, showed Amberen to be an effective, safe and well tolerated supplement.† The below percentages are the clinically shown results from the study.*

91 Percent

had reduced hot flashes*

97 Percent

had reduced stress*

78 Percent

had reduced night sweats*

73 Percent

had more sex drive*

80 Percent

had reduced mood swings*

71 Percent

had reduced headaches*

87 Percent

had less dificulty sleeping*

74 Percent

had reduced muscle & joint pain*

85 Percent

had reduced irritability*

63 Percent

had less excitability*

77 Percent

had more energy*

82 Percent

had less difficulty
concentrating*

87 Percent

had less dificulty sleeping*

74 Percent

had reduced muscle & joint pain*

85 Percent

had reduced irritability*

63 Percent

had less excitability*

77 Percent

had more energy*

82 Percent

had less difficulty
concentrating*

History Behind Amberen

Today’s Amberen formulation is the result of decades of sophisticated, rigorous testing, and scientific discoveries. Click below to learn more about our clinical studies and the scientific achievements from the last 45 years of research on the Amberen formulation and its main ingredients.

Scientific Research

Small doses of amber (succinic) acid were used to rejuvenate the hypothalamus by restoring its sensitivity.

V.M. Dilman, V.N. Anisimon, and M.N. Kondrashova. The influence of succinic (amber) and glutamic acids on the sensitivity of hypothalamo-gonadotropic system to inhibitory action of estrogens in old rats. Pharmacology and Toxicology 3, 540-551, 1976 (In Rus).

Scientific Research

In pre-clinical trials, succinic acid showed to improve menopausal changes and also exhibited very distinct signs of rejuvenation.

Dilman, V. M., and V. N. Anisimov. “Hypothalamic mechanisms of ageing and of specific age pathology—I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system.” Experimental gerontology 14.4 (1979): 161-173.

Scientific Research

Enerlit-Clima (equivalent of Amberen’s formulation) composition was developed. In preclinical trials, the supplement was shown to be safe (no acute or long-term toxicity) and to be effective for the alleviation of more than 12 menopausal symptoms.

Clinical Trial

Evaluation of Enerlit-Clima (equivalent of Amberen’s formulation) as a treatment for climacteric syndrome.

Study design: This randomized, placebo-controlled, double-blind, 3-week study involved 70 menopausal women.

Results: The results of the study demonstrated that Enerlit-Clima-based therapy helps alleviate many menopause symptoms when compared with the placebo group. No adverse side effects when taking Enerlit-Clima were registered.

Publication: Maevsky, E. I., et al. “A succinate-based composition reverses menopausal symptoms without sex hormone replacement therapy.” Advances in gerontology= Uspekhi gerontologii/Rossiiskaia akademiia nauk, Gerontologicheskoe obshchestvo 21.2 (2008): 298-305.

Scientific Research

A 3-year-long observational clinical study on 245 women was conducted. Enerlit-Clima (equivalent of Amberen’s formulation) was shown to be safe and effective when it came to managing several menopausal symptoms.

Scientific Research

A U.S. patent was granted to Lunada Biomedical (currently Boigix), which had acquired the rights to Amberen’s proprietary formulation in 2006 for a method of synthesizing biologically active succinic acid (Patent No: US 8,546,611 B2. Date of patent: Oct. 1, 2013).

Clinical Trial

Study design: A 12-week randomized, placebo-controlled, double-blind, study with 102 women between 42 and 60 years of age with mild to moderate menopause symptoms.

Results: Women who took Amberen showed statistically significant improvements compared to the placebo group. The results of the safety evaluation showed Amberen to be a safe dietary supplement.

Publications: Kuznetsova I.V. UYB, Borisova N.I., Zhukova E.V., Berdnikova N.G., Gusak Yu.K. Effectiveness of alternative therapy in perimenopausal and postmenopausal women (in Russian). Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2016 5:126 - 33.

Kuznetsova I.V, Uspenskaya Yu. B., Borisova N.I, Zhukova E.V., Berdnikova N.G., Gusak Yu. K Effectiveness and safety of using a succinate-based dietary supplement for women in menopause. Medline.ru, 2016, Vol 17, Art. 3, p 24-45 (Mecine.ru/pdf)

Presentations: Poster presentation at the 15th World Congress on Menopause. Effectiveness and safety of using Amberen supplementation in perimenopausal and postmenopausal women. Yu. Uspenskaya, I. Kuznetsova, N. Borisova, N. Berdnikova and U. Gusak

Clinical Trial

Study design: A 12-week randomized, placebo-controlled, double-blind study with 125 women between 42 and 60 years of age with mild to moderate menopause symptoms.

Results: Amberen was shown to be a safe and well-tolerated supplement with no adverse side effects. Compared to the placebo group, women who took Amberen reported significant improvements in many menopausal symptoms.

Publications: Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial. V. E. Radzinskii, I. V. Kuznetsova, Y. B. Uspenskaya, N. B. Repina, Y. K. Gusak, O. M. Zubova, D. I. Burchakov & A. A. Osmakova (2016) Gynecological Endocrinology, 32:sup2, 64-68, DOI: 10.1080/09513590.2016.1232686

Presentations: Oral presentation of the 2015/2016 Amberen clinical trial results By Y.B. Uspenskaya: International Menopause Society, 25th World Congress on Controversies in Obstetrics, Gynecology and Infertility, Amsterdam, Netherlands, November 10-13, 2016.

Research

Data from two trials were pooled in order to continue to evaluate and further confirm Amberen’s efficacy. The analysis of the larger data set showed that Amberen relieves 16 menopausal symptoms.

Viktor E. Radzinsky, Yulia Uspenskaya, Lee P. Shulman, and Irina V. Kuznetsova. Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials. Obstetrics and Gynecology International, vol. 2019, Article ID 1572196, 9 pages, 2019. https://doi.org/10.1155/2019/1572196.

Amberen is an innovative, clinically tested dietary supplement that helps relieve most common symptoms of menopause by restoring hormonal balance. Amberen’s proprietary blend of succinates, amino acids, minerals, and vitamin E has been clinically shown to stimulate the production of female hormones without any adverse side effects.** Amberen’s benefits are backed by double-blind, randomized, placebo-controlled, human clinical trials on menopausal women and over 45 years of scientific and clinical research on the main ingredients.* Amberen does not contain any hormones and is not a hormone replacement treatment. Amberen is not a prescription drug.

Amberen provides single relief for common perimenopause and menopause symptoms. Symptom relief includes the following: hot flashes, night sweats, mood swings, low energy and fatigue, sleeplessness, difficulty concentrating, irritability, menopausal headaches and stress, lack of sexual interest, muscle and joint aches, plus menopausal weight gain.*

Menopausal symptoms are caused by age-related decline of estrogen. If taken as directed, Amberen targets the root cause of menopause and restores hormonal balance by stimulating your body’s natural production of estrogen,† with no adverse side effects.**

Amberen is an innovative dietary supplement because of its unique and proprietary ingredients and mechanism of action. Unlike other products, Amberen targets the underlying cause of menopausal symptoms by restoring hormonal balance and with no adverse side effects.** It contains no hormones, soy, black cohosh, or other herbs. Multiple clinical human studies on its formulation showed that Amberen is effective for perimenopause and menopause. Plus, Amberen uniquely offers women free consultations via NurseAid. NurseAid is a complimentary phone consultation service provided by Amberen and is comprised of a team of professionals led by a licensed nurse.

Yes. Amberen has been tested in three randomized, double-blind, placebo-controlled human clinical trials. Additionally, Amberen is backed by over 45 years of scientific research. Read more about the science behind Amberen here.

Amberen is not a weight loss product. Amberen’s most recent clinical studies have shown that it helps manage weight gain during menopause when taken as recommended for 90 days.* It is recommended that Amberen be taken in combination with enjoying a healthy diet and exercise.

Amberen is a proprietary blend of succinates, amino acids, minerals, and vitamin E. Amberen’s main ingredients are produced via a U.S. patented manufacturing process that guarantees their unique bioavailability. Amberen ingredients are as follows: ammonium succinate, calcium disuccinate, magnesium disuccinate, zinc difumarate, glycine, monosodium L-glutamate, tocopheryl acetate. Amberen is available in gelatin capsules. For more information about Amberen ingredients, please click here.

No, Amberen doesn't contain estrogen or soy. Amberen also does not contain black cohosh, herbs, or maca.
Feel Like Yourself Again

Questions? call nurseaid††at:
(800) 211-8021(800) 211-8021