Scientific & Clinical Research

Trust in a product is essential when selecting a supplement, especially if you are seeking to relieve bothersome perimenopausal symptoms. If you’re going through perimenopause and are in your mid-thirties or later, you might be wanting some comfort in knowing that the product is not only effective but also safe to take. Our main ingredients have been studied and researched for more than 45 years, and the success of our core formulation is now complemented by a newly designed formula for perimenopausal women just like you.

Expert Opinion

“In my practice, I see many perimenopausal women. To have a non-hormonal supplement option is a great advantage. New clinically tested Amberen Perimenopause provides effective relief from sleeplessness, stress and anxiety, fatigue and other perimenopausal symptoms.”

Prof. Lee Shulman
M.D., OB-GYN
Amberen’s Board of
Scientific Advisors

“In my practice, I see many perimenopausal women. To have a non-hormonal supplement option is a great advantage. New clinically tested Amberen Perimenopause provides effective relief from sleeplessness, stress and anxiety, fatigue and other perimenopausal symptoms.”

Prof. Lee Shulman
M.D., OB-GYN
Amberen’s Board of
Scientific Advisors

Clinically Shown Results

Clinically Shown Results

Amberen’s newly designed perimenopause formula has been clinically tested on 105 perimenopausal women between the ages of 36-50 with mild to moderate symptoms. The results of this 6-month double-blind, randomized, and placebo-controlled study show that our new formula is an effective, safe and well-tolerated supplement for perimenopause. In fact, 74% of perimenopausal women experienced menstrual regularity^ and relief from the following symptoms:

92 Percent

had reduced hot flashes*

98 Percent

had reduced anxiety and stress*

89 Percent

had reduced night sweats*

86 Percent

had less fatique*

82 Percent

had reduced mood swings*

74 Percent

had more sex drive*

82 Percent

had less dificulty sleeping*

68 Percent

had reduced headaches*

72 Percent

had reduced irritability*

61 Percent

had reduced muscle & joint pain*

98 Percent

had reduced anxiety and stress*

86 Percent

had less fatique*

74 Percent

had more sex drive*

68 Percent

had reduced headaches*

61 Percent

had reduced muscle & joint pain*

History Behind Amberen Perimenopause

Today’s Amberen formulation is the result of decades of sophisticated, rigorous testing, and scientific discoveries. Click below to learn more about our clinical studies and the scientific achievements from the last 45 years of research on the Amberen formulation and its main ingredients.

Scientific Research

Study Design: A 180-day (90-day intervention followed by 90-day observation) randomized, placebo-controlled, double-blind study with 105 women between 36 and 50 years of age with mild to moderate perimenopausal symptoms.

Results: Amberen Perimenopause was shown to be a safe and well-tolerated supplement with no adverse side effects. Compared to the placebo group, women who took Amberen reported significant improvements in many perimenopause symptoms. Perimenopausal women who participated in the clinical trial experienced menstrual regularity.^

Scientific Research

In pre-clinical trials, succinic acid showed to improve menopausal changes and the animals also exhibited very distinct signs of rejuvenation. Their energy levels increased, yellow patches disappeared from their fur, their eyes brightened, and their behavioral patterns were similar to those of much younger animals.

Dilman, V. M., and V. N. Anisimov. “Hypothalamic mechanisms of ageing and of specific age pathology—I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system.” Experimental gerontology 14.4 (1979): 161-173.

Scientific Research

Small doses of amber (succinic) acid were used to rejuvenate the hypothalamus by restoring its sensitivity.

V.M. Dilman, V.N. Anisimon, and M.N. Kondrashova. The influence of succinic (amber) and glutamic acids on the sensitivity of hypothalamo-gonadotropic system to inhibitory action of estrogens in old rats. Pharmacology and Toxicology 3, 540-551, 1976 (In Rus).

Scientific Research

Study Design: A 180-day (90-day intervention followed by 90-day observation) randomized, placebo-controlled, double-blind study with 105 women between 36 and 50 years of age with mild to moderate perimenopausal symptoms.

Results: Amberen Perimenopause was shown to be a safe and well-tolerated supplement with no adverse side effects. Compared to the placebo group, women who took Amberen reported significant improvements in many perimenopause symptoms. Perimenopausal women who participated in the clinical trial experienced menstrual regularity.^

Scientific Research

In pre-clinical trials, succinic acid showed to improve menopausal changes and the animals also exhibited very distinct signs of rejuvenation. Their energy levels increased, yellow patches disappeared from their fur, their eyes brightened, and their behavioral patterns were similar to those of much younger animals.

Dilman, V. M., and V. N. Anisimov. “Hypothalamic mechanisms of ageing and of specific age pathology—I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system.” Experimental gerontology 14.4 (1979): 161-173.

Scientific Research

Small doses of amber (succinic) acid were used to rejuvenate the hypothalamus by restoring its sensitivity.

V.M. Dilman, V.N. Anisimon, and M.N. Kondrashova. The influence of succinic (amber) and glutamic acids on the sensitivity of hypothalamo-gonadotropic system to inhibitory action of estrogens in old rats. Pharmacology and Toxicology 3, 540-551, 1976 (In Rus).

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